AbstractIn this paper, we introduce Hermite-Chebyshev polynomials of two variables and to give some properties of Hermite and Chebyshev polynomials of two variables. We derive series representation, operational identities, generating functions and power series method by Hermite, Chebyshev and Hermite-Chebyshev polynomials of two variables. Finally, we consider generalized Hermite-Chebyshev polynomials of two variables and explicit representation of Hermite-Chebyshev polynomials of two variables.